Studies in Testosterone Hormone Level in Ram Affected with Fascioliasis (Physiopathological Studies)

Out of the 830 examined livers of ram, of different ages and sexes were slaughtered at abattoirs of Cairo, Giza provinces during the period from January 2014 to October 2014, the incidences of Fascioliasis was recorded in 117 (14.1 %). Highly significant decreases in serum cholesterol, High density lipoprotein HDL and Low density Lipoprotein LDL (p<0.01) were recorded in our study in chronic fascioliasis .While in acute fascioliasis the serum cholesterol, HDL and LDL levels had significantly decreased (p<0.05) in all. Testosterone concentration was found to be significantly decreased (p>0.05) in rams, suffered from chronic fascioliasis. On the other hand, the results showed that there were no significant differences in testosterone concentration in acute fascioliasis. Lesions in acute fascioliasis were severe. Congestion, hemorrhagic migrating tracts formed from degenerated hepatocytes, erythrocytes and eosinophil's beside old parasitic tracts represented by central necrosis surrounded with eosinophil's, macrophages and lymphocytes together with connective tissue capsule.TEM of liver showed eosinophil cells with its characteristic granules. Chronic fascioliasis was characterized by presence of liver flukes in the lumen of the bile ducts. TEM of liver had shown prominent degeneration of the cell organelles. The testes in chronic fascioliasis displayed thickening of tunica albuginea, in addition to leydig cells were found isolated or in small clusters. TEM, showed necrotic leydig cells having deformed mitochondria, reduced smooth endoplasmic reticulum and few lipid droplets.